Wound Care research

One of the most prevalent uses for hyperbaric oxygen therapy is wound care. Much research, therefore, has already been carried out on its usefulness and efficacy in aiding in the healing of wounds. There is still, however, ongoing research:

  • A study, sponsored by the Mrs. Thelma Zoegas Foundation, on hyperbaric oxygen therapy as adjunctive treatment of chronic diabetic foot ulcers, hoping to evaluate if hyperbaric oxygen therapy heels more foot ulcers as compared to placebo in patients with diabetes mellitus and chronic foot ulcers.110
  • A study, sponsored by the National Center for Complementary and Alternative Medicine, on the efficacy of hyperbaric oxygen therapy for laryngectomy patients, hoping to develop a predictive model for the development of wound complications in patients undergoing laryngectomy surgery for laryngeal/adjoining structure cancers, and to evaluate the clinical efficacy of hyperbaric oxygen for the prevention/management of wound complications in this previously irradiated population.111
  • A study, sponsored by St. Joseph’s Healthcare Hamilton, on hyperbaric oxygen therapy for chronic diabetic lower limb ulcers, hoping to determine if HBOT plus standard wound care is more effective than standard wound care alone at preventing the need for major amputation (metatarsal and up) in patients with diabetes mellitus (Type 1 or 2) with moderate to severe chronic wounds of lower limbs.112
  • A study, sponsored by Oslo University Hospital, on hyperbaric oxygen treatment as adjuvant treatment for frost injury, hoping to discover weather hyperbaric oxygen treatment is beneficial as adjuvant treatment for frost damage.113
  • A study, sponsored by Singapore General Hospital, on the effects of hyperbaric oxygen therapy on acute thermal burns, hoping to determine the effects of hyperbolic oxygen therapy on burns conversion for patients who have fresh thermal burns injury using the LDI, objectively determine the proportion of burns conversion in areas of partial thickness burns for early thermal burns injury in both arms of the RCT, Study the effects of HBOT on immunological markers IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and TGF-β ( comparison between both arms and 2 assessment points), study the effect of HBOT on haematological markers including procalcitonin, albumin, lymphocyte counts, neutrophil count, and macrophage count, study the effects of HBOT on histology specimens in quantifying P53 protein, leukocyte and macrophage infiltration, burns depth assessment and vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS), and study the effects of HBOT on bacteriology of tissue culture in areas of deep dermal burns.114
  • A study, sponsored by Bayside Health, on hyperbaric oxygen in lower leg trauma, hoping to discover whether hyperbaric oxygen prevents complications and improves outcomes in severe lower limb trauma.115
  • A study, sponsored by RWTH Aachen University, on hyperbaric oxygen therapy in calcaneal intraarticular fractures, hoping to determine whether postoperative daily hyperbaric oxygen therapy (HBOT) decreases soft-tissue complication rate during the operative handling of intra-articular calcaneal fractures.116

Notes
110http://clinicaltrials.gov/ct2/show/NCT00953186?cond=%22Hyperbaric+Oxygenation%22&rank=13
111http://clinicaltrials.gov/ct2/show/NCT00026975?cond=”H
112http://www.clinicaltrials.gov/ct2/show/NCT00621608?term=hyperbaric+oxygen+therapy&rank=6
113http://www.clinicaltrials.gov/ct2/show/NCT01270477?term=hyperbaric+oxygen+therapy&rank=49
114http://clinicaltrials.gov/ct2/show/NCT00824551?cond=%22Hyperbaric+Oxygenation%22&rank=5
115http://clinicaltrials.gov/ct2/show/NCT00264511?recr=Open&cond=hyperbaric&state1=NA%3AUS&rank=7
116http://clinicaltrials.gov/ct2/show/NCT01264146?cond=%22Hyperbaric+Oxygenation%22&rank=4